Journal article
Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8 T Cells in Human Lymphoid Organs
HG Woon, A Braun, J Li, C Smith, J Edwards, F Sierro, CG Feng, R Khanna, M Elliot, A Bell, AD Hislop, SG Tangye, AB Rickinson, T Gebhardt, WJ Britton, U Palendira
Plos Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
Disruption of T cell memory during severe immune suppression results in reactivation of chronic viral infections, such as Epstein Barr virus (EBV) and Cytomegalovirus (CMV). How different subsets of memory T cells contribute to the protective immunity against these viruses remains poorly defined. In this study we examined the compartmentalization of virus-specific, tissue resident memory CD8+ T cells in human lymphoid organs. This revealed two distinct populations of memory CD8+ T cells, that were CD69+CD103+ and CD69+CD103—, and were retained within the spleen and tonsils in the absence of recent T cell stimulation. These two types of memory cells were distinct not only in their phenotype a..
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Grants
Awarded by Medical Research Council
Funding Acknowledgements
This project was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia and the NSW Government Infrastructure Grant to the Centenary Institute. UP is the recipient of a Career Development Fellowship from the Cancer Institute New South Wales. ABr is the recipient of a research fellowship from the German Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.